Author

Coert Margadant

Leiden UniversityORCID 0000-0002-5957-6683Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

C. Ellen van der SchootiD· 1 shared Eleftherios ZarkadasiD· 1 shared Femke S. van der Meer· 1 shared Francisco Javier ChichóniD· 1 shared Gestur VidarssoniD· 1 shared José M. de PeredaiD· 1 shared Junichi TakagiiD· 1 shared Marcos GrageraiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiophysics

C. Ellen van der SchootORCID

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1 paper

Recent·Most cited

BiophysicsScience AdvancesPeer-reviewedJul 17, 2026

High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation

José M. de Pereda, Wendy Stam, Marcos Gragera…·Coert Margadant

This study presents the high-resolution cryo-EM structure of integrin αIIbβ3 bound to an anti-HPA-1a antibody, revealing how it blocks integrin activation and platelet aggregation.

DOI 10.1126/sciadv.aed9833

humancryo-EM

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