Author

Kath Hardcastle

Moderna Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:multiome· 1 Organism:non-human primate· 1

Frequent Co-Authors

Andrea Carfı́iD· 3 shared Alec W. FreyniD· 2 shared Amy Gorrie· 2 shared Arshan NasiriD· 2 shared Cathal HarmoniD· 2 shared Daniel L. MakrinosiD· 2 shared Daniela Montes Berrueta· 2 shared Darin K. EdwardsiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Andrea Carfı́ORCID

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3 papers

Recent·Most cited

A multivalent mRNA-LNP therapeutic vaccine with broad cross-genotype immunogenicity elicits clearance of HBV infected hepatocytes

Daniel L. Makrinos, Yanbo Sun, Heather L. Davis, LingZhi Ma, Thu Kim, Emma Dellea, Mia Malone, Edison Ong, Maria Cavallaro, Caroline G. Atyeo, Phillipa Martin, Cathal Harmon, Ziqiu Wang, Guha Asthagiri Arunkumar, Alec W. Freyn, , Simone Pecetta

This paper develops an mRNA-LNP vaccine, mRNA-1965, that clears HBV-infected hepatocytes in mice by inducing broad immune responses across HBV genotypes.

bioRxiv · Dec 5, 2025 · PreprintImmunology

mRNA-1273.251 and mRNA-1283.251 vaccines expressing SARS-CoV-2 variant LP.8.1 antigens broadly neutralize contemporary JN.1-lineage viruses

Arshan Nasir, Diana Wing Lee, Ziqiu Wang, Clinton O. Ogega, Nathen E. Bopp, Phylicia Wisti, Daniel L. Makrinos, Hardik Jani, Amy Gorrie, Michael F. Bender, Adrian R. Laciak, Arvind Sharma, Xiaozhen Hu, Tessa Speidel, Fadi Ghantous, , Alec W. Freyn

This study develops and evaluates two mRNA vaccines targeting the LP.8.1 variant of SARS-CoV-2, showing broad neutralization against JN.1-lineage subvariants.

bioRxiv · Sep 16, 2025 · PreprintImmunology

mRNA-1273 vaccines adapted to JN.1 or KP.2 elicit cross-neutralizing responses against the JN.1 sublineages of SARS-CoV-2 in mice

Diana Wing Lee, Arshan Nasir, Sayda M. Elbashir, Hardik Jani, Tessa Speidel, Amy Gorrie, Daniela Montes Berrueta, Philippa Martin, Swan Tan, Yixuan Jacob Hou, Kath Hardcastle, Darin K. Edwards, Kai Wu, Andrea Carfı́, Yadunanda Budigi

This study evaluates JN.1 and KP.2 mRNA vaccines in mice, showing they elicit strong neutralizing antibodies against JN.1 subvariants and cross-neutralize KP.3, LA.2, and XEC.

Vaccine · Mar 7, 2025Peer-reviewedImmunology