Paula Turkki

This paper introduces a genetically programmable hydrogel platform to create precision recombinant human ECM mimics with tunable mechanical and biological properties.

The paper shows that the A50I vinculin mutation is not talin-binding-null and that talin is essential for organizing vinculin tension gradients in focal adhesions.

This paper identifies an aggregation-prone region in talin that drives self-interactions and regulates integrin adhesion complex dynamics through mechanical unfolding and oligomerization.

This paper uses visible light to control specific protein reactions in mammalian cells, revealing early stages of cell adhesion and mechanotransduction.