Yanyu Guo

Highly conserved talin isoforms encode distinct mechanical responses and ligand-binding capabilities

This study examines how sequence differences between talin-1 and talin-2 affect their mechanical responses and ligand-binding capabilities, revealing distinct mechanical behaviors and new interaction sites in talin-2.

Talin controls the spatial distribution of vinculin tension in focal adhesions

The paper shows that the A50I vinculin mutation is not talin-binding-null and that talin is essential for organizing vinculin tension gradients in focal adhesions.

An Aggregation Prone Region (APR) in talin controls talin self-interactions to regulate integrin adhesion complex dynamics

This paper identifies an aggregation-prone region in talin that drives self-interactions and regulates integrin adhesion complex dynamics through mechanical unfolding and oligomerization.