Nicholas H. Brown

FlyAnatoView: Visualization of Drosophila Single-cell RNA-seq Datasets on Anatomographs

FlyAnatoView projects Drosophila scRNA-seq data onto anatomical diagrams to restore spatial context and enable exploration of gene expression patterns across tissues.

Talin controls the spatial distribution of vinculin tension in focal adhesions

The paper shows that the A50I vinculin mutation is not talin-binding-null and that talin is essential for organizing vinculin tension gradients in focal adhesions.

An Aggregation Prone Region (APR) in talin controls talin self-interactions to regulate integrin adhesion complex dynamics

This paper identifies an aggregation-prone region in talin that drives self-interactions and regulates integrin adhesion complex dynamics through mechanical unfolding and oligomerization.

A new experimental evidence-weighted signaling pathway resource in FlyBase.

The paper curates 17 Drosophila signaling pathways using experimental evidence and integrates them into FlyBase with visualization tools.

PANGEA: A New Gene Set Enrichment Tool for Drosophila and Common Research Organisms

PANGEA is a new GSEA tool that allows flexible analysis of gene sets using various annotations, enhancing visualization and comparison of results for Drosophila and other organisms.

FlyPhoneDB: An integrated web-based resource for cell-cell communication prediction in Drosophila

FlyPhoneDB predicts cell-cell communication in Drosophila using scRNA-seq data by calculating interaction scores between ligand-receptor pairs.

Integrin signaling downregulates filopodia in muscle-tendon attachment

The paper shows integrin signaling suppresses filopodia in Drosophila myotubes during muscle-tendon attachment, enabling actin machinery to form strong attachments.

Novel functions for integrin-associated proteins revealed by myofibril attachment in Drosophila

The paper identifies new functions of integrin-associated proteins in Drosophila myotendinous junctions, revealing their roles in regulating adhesion and mechanotransduction.