Vesa Pekka Hytönen

Genetically programmable molecular framework for constructing precision recombinant human ECM mimics

This paper introduces a genetically programmable hydrogel platform to create precision recombinant human ECM mimics with tunable mechanical and biological properties.

Discovering age- and sex-specific genetic risk factors in sensorineural hearing loss: genome-wide evidence from large-scale biobank studies

This study identifies 32 new SNHL risk loci through genome-wide meta-analyses of 531,059 individuals, including age- and sex-specific differences.

Talin controls the spatial distribution of vinculin tension in focal adhesions

The paper shows that the A50I vinculin mutation is not talin-binding-null and that talin is essential for organizing vinculin tension gradients in focal adhesions.

An Aggregation Prone Region (APR) in talin controls talin self-interactions to regulate integrin adhesion complex dynamics

This paper identifies an aggregation-prone region in talin that drives self-interactions and regulates integrin adhesion complex dynamics through mechanical unfolding and oligomerization.

Structural insight into rabies virus neutralization revealed by an engineered antibody scaffold

This paper determines the crystal structure of an engineered antibody diabody bound to rabies virus glycoprotein, revealing a conserved epitope and mechanism of neutralization.

Visible light-induced specific protein reaction delineates early stages of cell adhesion

This paper uses visible light to control specific protein reactions in mammalian cells, revealing early stages of cell adhesion and mechanotransduction.