Patterning and folding of intestinal villi by active mesenchymal dewetting
Tyler R. Huycke, Teemu J. Häkkinen, Hikaru Miyazaki, Vasudha Srivastava, Emilie Barruet, Christopher S. McGinnis, Ali Kalantari, Jake Cornwall-Scoones, Dedeepya Vaka, Qin Zhu, Hyunil Jo, Roger Oria, Valerie Marie Weaver, William F. DeGrado, Matt W. Thomson, , Zev J. Gartner
This study identifies an active mechanical mechanism involving PDGFRA+ mesenchymal cells that pattern and fold intestinal villi through myosin II-dependent forces and matrix metalloproteinase-mediated tissue fluidization.
Cell · May 22, 2024Peer-reviewedDevelopmental Biology