Vasudha Srivastava

The paper shows that mechanical sorting, driven by adhesion and contractility differences, maintains basal-luminal compartmentalization and influences lineage outcomes in glandular epithelia.

This study uses single-cell RNA-sequencing to track how Pik3caH1047R mutation drives mammary tumor progression by altering epithelial and fibroblast transcriptional states.

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

This study shows that swirling motion of breast cancer cells aligns collagen fibers radially, enabling collective invasion by generating contractile stresses.

This study identifies an active mechanical mechanism involving PDGFRA+ mesenchymal cells that pattern and fold intestinal villi through myosin II-dependent forces and matrix metalloproteinase-mediated tissue fluidization.

The paper introduces MULTI-seq, a method for scalable sample multiplexing in scRNA-seq, enabling analysis of multiple tissues and perturbation experiments while improving data quality.