Author

María José Sánchez-Barrena

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-5986-1804Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:deep learning· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alicia MansillaiD· 2 shared Celia Miró-Rodríguez· 2 shared Daniel Muñoz-ReyesiD· 2 shared Sara Pérez-Suárez· 2 shared Abraham Acevedo‐ArozenaiD· 1 shared Aurea B. Martins-BachiD· 1 shared Brian J. NiemaniD· 1 shared Carlos Requena-TrigueroiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

Alicia MansillaORCID

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Author profile →

3 papers

Recent·Most cited

FDA drug repurposing uncovers modulators of dopamine D2 receptor localization via disruption of the NCS-1 interaction

Daniel Muñoz-Reyes, Lorena Aguado, Sandra Arroyo‐Urea, Carlos Requena-Triguero, Sara Pérez-Suárez, Sonia Sánchez-Yepes, Josep Argerich, Celia Miró-Rodríguez, Eugenia Ulzurrun, Eulalia Rodríguez‐Martín, Javier García‐Nafría, Nuria Eugenia Campillo, Alicia Mansilla, María José Sánchez-Barrena

The paper identifies FDA-approved drugs that disrupt the NCS-1/D2R interaction, modulating D2R localization without affecting its signaling.

Journal of Medicinal Chemistry · Nov 10, 2025Peer-reviewedBiochemistry

Combining crystallographic fragment screening, algorithmic merging and digitized chemical synthesis efficiently yields scaffolds that target diverse NCS-1 protein-protein interactions implicated in neurological disorders

Daniel Muñoz-Reyes, Kate K. Fieseler, Max Winokan, Mathew Golding, Eda Çapkın, Matteo Paolo Ferla, Sara Pérez-Suárez, Charlie W. E. Tomlinson, Peter George Marples, Celia Miró-Rodríguez, Alicia Mansilla, D. Fearon, Warren Thompson, F. von Delft, María José Sánchez-Barrena

This paper combines crystallographic fragment screening, algorithmic merging, and automated synthesis to generate scaffolds targeting NCS-1 PPIs involved in neurological disorders.

bioRxiv · Jun 18, 2025 · PreprintBiophysics

TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43.

Juan Miguel Godoy-Corchuelo, Zeinab Ali, José Miguel Brito Armas, Aurea B. Martins-Bach, Irene García-Toledo, Luis C. Fernández-Beltrán, Juan Ignacio López‐Carbonero, Pablo Bascuñana, Shoshana Spring, Irene Jiménez-Coca, Ramón A. Muñoz de Bustillo Alfaro, María José Sánchez-Barrena, R. Nair, Brian J. Nieman, Jason P. Lerch, , Silvia Corrochano

This study characterizes a mouse model with TDP-43 M323K mutation, showing cognitive, motor, and structural brain abnormalities linked to TDP-43 mislocalization and increased levels.

Neurobiology of Disease · Feb 15, 2024Peer-reviewedNeuroscience