Distinct roles for canonical and variant histone H3 lysine 36 in Polycomb silencing
Harmony R. Salzler, Vasudha Vandadi, Benjamin D. McMichael, John C. Brown, Sally A. Boerma, Mary P Leatham-Jensen, Kirsten M. Adams, Michael P. Meers, Jeremy M. Simon, Robert J. Duronio, Daniel J. McKay, A. Gregory Matera
The paper shows that H3.2 and H3.3 K36 residues have distinct roles in maintaining Polycomb silencing of Hox genes through different mechanisms, enabling development.
Science Advances · Mar 1, 2023Peer-reviewedGenomics