Author

Johan Panek

University of California San DiegoORCID 0000-0002-6026-9875Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:C. elegans· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Emily R. TroemeliD· 2 shared Kirthi C. ReddyiD· 2 shared Amitkumar Fulzele· 1 shared Congsing Sun· 1 shared David WangiD· 1 shared Edward FielderiD· 1 shared Efrem S. LimiD· 1 shared Eric J. BennettiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersGenetics

Emily R. TroemelORCID

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3 papers

Recent·Most cited

Cell BiologyJournal of Biological ChemistryPeer-reviewedAug 11, 2026

Activation of pro-survival autophagy by a small molecule promoting p62 oligomerisation

Johan Panek, Edward Fielder, Congsing Sun…·Viktor I. Korolchuk

The paper identifies SQ-1 as a small molecule that activates autophagy by promoting p62 oligomerisation, improving mitochondrial clearance and cell viability in NPC1 disease models.

DOI 10.1016/j.jbc.2026.113430

humanproteomics

𝕏 PostBluesky

GeneticsbioRxivPreprintOct 22, 2019

A cullin-RING ubiquitin ligase promotes thermotolerance as part of the Intracellular Pathogen Response in C. elegans

Johan Panek, Spencer S. Gang, Kirthi C. Reddy…·Emily R. Troemel

3 citations

C. elegansexperimental assay

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GeneticsCurrent BiologyPeer-reviewedNov 1, 2017

An Intracellular Pathogen Response Pathway Promotes Proteostasis In C. elegans

Kirthi C. Reddy, Tal Dror, Jessica N. Sowa…·Emily R. Troemel

This study identifies a novel pathway, the Intracellular Pathogen Response (IPR), that promotes proteostasis in C. elegans by upregulating ubiquitin ligase components like cul-6, with pals-22 acting as a repressor.

133 citations

C. elegansexperimental assay

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