Kirthi C. Reddy

This study identifies conserved autism-associated genes that regulate social feeding behavior in C. elegans through distinct synaptic mechanisms.

The paper shows that the neurexin {gamma} isoform is required for glycerol avoidance in adult C. elegans, while other isoforms are needed in juveniles.

This study shows that exposure to P. aeruginosa in C. elegans reduces brood size by inducing programmed germ cell death and mitotic quiescence, which are reversible upon removal of the pathogen.

This study shows dopamine signaling in C. elegans regulates egg-laying behavior in response to predator presence, with specific receptor combinations mediating predator-induced and baseline egg-laying changes.

This paper shows that food deprivation in C. elegans reduces repellent sensitivity, mediated by intestinal transcription factors and insulin signaling to neurons, leading to riskier behaviors.

This study shows that neuropeptides regulate intestinal integrity and aging in invertebrates, with effects modulated by the germline.

This study identifies two mechanosensitive proteins, TRP-4 and MEC-4, that work in parallel to mediate ultrasound-evoked behavioral responses in C. elegans.

This study identifies two C. elegans-specific genes, pals-22 and pals-25, which function as antagonistic regulators controlling the switch between growth and pathogen resistance.

This study identifies a novel pathway, the Intracellular Pathogen Response (IPR), that promotes proteostasis in C. elegans by upregulating ubiquitin ligase components like cul-6, with pals-22 acting as a repressor.