Bernhard Hube

This study identifies SmpR as a transcription factor that coordinates secondary metabolism and antibacterial defense in A. fumigatus in response to bacterial signals.

This study investigates how substitutions at positions K13 and K17 in histatin 5 affect its proteolytic stability and antifungal activity against Candida albicans.

This study shows that local albumin excess in the vagina exacerbates Candida albicans-induced inflammasome activation, contributing to hyperinflammation in vulvovaginal candidiasis.

This study investigates how cells repair damage from the fungal toxin candidalysin compared to bacterial pore-forming toxins, finding distinct Ca2+-dependent mechanisms and roles for MEK and annexins.

This study shows hepcidin deficiency increases susceptibility to Candida albicans infection by promoting fungal growth and kidney damage, and suggests hepcidin mimetics as a potential treatment.

The paper identifies a single amino acid change in fungal proteins that enables phagosomal membrane penetration, suggesting convergent evolution of virulence mechanisms across fungi.

The paper identifies toxic intermediates in fungal metabolic pathways as potential antifungal targets using a random forest model and provides a web-service for exploration.