John Spencer

This paper develops a pipeline to identify and evaluate novel manganese chelators using zebrafish and mouse models, finding that H3PyC3A and Me3PyC3A show improved manganese mobilization and reduced accumulation.

This study shows that CBD, THC, and terpenes inhibit mouse DRG neuron excitability, with synergistic effects suggesting potential for non-opioid analgesics.

The paper reports the structural analysis of a minimal kinase domain of HRI, showing its ligand-binding conformation and non-productive state, supporting drug discovery for blood cancer.

This study shows that the balance between B55α and Greatwall expression levels determines cancer cell sensitivity to Greatwall inhibition.

The paper presents the crystal structure of the Hsp90-LA1011 complex and suggests LA1011 may improve Alzheimer's disease prognosis by disrupting FKBP51 binding to Hsp90.

This study shows that ADLL and its enantiomer ALL slow disease progression in lysosomal storage disorders through mechanisms involving glucose and antioxidant metabolism.