This paper presents a comprehensive metabolomic analysis of human heart tissue using parallel extraction methods and high-resolution mass spectrometry to identify 2276 metabolites across a wide range of polarities.

Analytical Chemistry · Apr 3, 2024Peer-reviewedMolecular Biology

A Multi-omics Method Enabled by Sequential Metabolomics and Proteomics for Human Pluripotent Stem Cell-derived Cardiomyocytes

Elizabeth F. Bayne, Aaron D. Simmons, David S. Roberts, Yanlong Zhu, Timothy J. Aballo, Benjamin Wancewicz, Sean P. Palecek, Ying Ge

The paper develops a multi-omics method to analyze metabolome and proteome of hPSC-CMs, identifying overrepresented pathways in protein synthesis and cardiac function.

Journal of Proteome Research · Sep 9, 2021Peer-reviewedSystems Biology

A comprehensive plasma metabolomics dataset for a cohort of mouse knockouts within the international mouse phenotyping consortium

Dinesh Kumar Barupal, Ying Zhang, Tong Shen, Sili Fan, Bryan S. Roberts, Patrick Fitzgerald, Benjamin Wancewicz, Luis Valdiviez, Gert Wohlgemuth, Gregory Byram, Ying Yng Choy, Bennett D Haffner, Megan Reed Showalter, Arpana Vaniya, Clayton S. Bloszies, , Oliver Fiehn

The paper provides a metabolomics dataset from 30 mouse gene knockouts and wildtypes, identifying 832 metabolites across multiple analytical methods.

Metabolites · May 22, 2019Peer-reviewedBioinformatics