Xavier Bledsoe

Dynamic responses to rejection in the transplanted human heart revealed through spatial transcriptomics

This study uses spatial transcriptomics to analyze gene expression in heart transplant recipients during rejection, identifying distinct transcriptomic profiles associated with different rejection types and outcomes.

Neuroimaging PheWAS and molecular phenotyping implicate PSMC3 in Alzheimer's Disease

The paper links PSMC3 expression to Alzheimer's Disease through neuroimaging and genetic analyses, showing its association with brain structure changes and dementia family history.

Genome sequencing of 35,024 predominantly African ancestry persons addresses gaps in genomics and healthcare

This study sequenced 35,024 individuals with predominantly African ancestry to address gaps in genomics and healthcare, finding under-documented disease variants and novel associations with drug adverse events and glycemic control.

Prognostic Value of Multiplexed Assays of Variant Effect and Automated Patch-clamping for KCNH2-LQTS Risk Stratification

This paper evaluates how functional variant data and penetrance estimates improve risk stratification for LQTS in KCNH2 missense variant carriers.

A Transcriptomic Atlas of the Human Brain Reveals Genetically Determined Aspects of Neuropsychiatric Health

The paper generates a transcriptomic atlas of the human brain using UK Biobank data to link gene expression with neuroimaging phenotypes, revealing genetically determined aspects of neuropsychiatric health.