Author

Anna J. Smith

Vanderbilt University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Jeffrey M. SpragginsiD· 2 shared Alan J. SimmonsiD· 1 shared Alexander N. PereziD· 1 shared Angela M. Taravella OilliD· 1 shared Aniket S. RaliiD· 1 shared Arianna L. Williams-KatekiD· 1 shared Audra M. JuddiD· 1 shared D. Marshall BrinkleyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Jeffrey M. SpragginsORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multimodal Imaging of the Cellular and Extracellular Microenvironment on the Same Formalin-Fixed Paraffin-Embedded Tissue Section

Jade K. Macdonald, Thai H. Pham, Alan J. Simmons, Harsimran Kaur, Jamie L. Allen, Anna J. Smith, Audra M. Judd, Seung Woo Kang, Madeline E. Colley, Melissa A. Farrow, Ken S. Lau, Jeffrey M. Spraggins

The paper develops an optimized multimodal imaging workflow that preserves tissue integrity and enables comprehensive profiling of morphology, collagen, cell populations, N-glycans, and extracellular matrix peptides from a single tissue section.

bioRxiv · Aug 24, 2026 · PreprintBiochemistry

Dynamic responses to rejection in the transplanted human heart revealed through spatial transcriptomics

Kaushik V Amancherla, Angela M. Taravella Oill, Xavier Bledsoe, Arianna L. Williams-Katek, Nelson Chow, Anna J. Smith, Melissa A. Farrow, Shilin Zhao, Quanhu Sheng, David W. Bearl, Alexander N. Perez, Robert Hoffman, Jonathan Nathan Menachem, Hasan Khalid Siddiqi, D. Marshall Brinkley, , Ravi V. Shah

This study uses spatial transcriptomics to analyze gene expression in heart transplant recipients during rejection, identifying distinct transcriptomic profiles associated with different rejection types and outcomes.

Nature Cardiovascular Research · Aug 10, 2026Peer-reviewedGenomics

A targeted cell lysis mechanism facilitates toxin release in Clostridioides difficile

Shannon Lynn Kordus, Kateryna Nabukhotna, Rubén Cano Rodríguez, Evan Krystofiak, Kevin O. Childress, Anna J. Smith, Oleg Kovtun, Natalie Loveridge, W. C. Ball, Grace Moore, Mary Kay Washington, Nicholas O. Markham, Dana Borden Lacy

The paper identifies a targeted cell lysis mechanism driven by TcdE that facilitates toxin release in Clostridioides difficile, revealing it as a bet-hedging strategy.

bioRxiv · Sep 22, 2025 · PreprintMicrobiology