Autoantibody origins in lupus and in relapse post CAR-T therapy
Amalie Grenov, Jongwon Yoon, Daniel M. Snell, Anna Mikolajczak, Hao Wang, Erdem Gürel, Ana Rodríguez-Ronchel, Gülçin Yeğen, Lydia S.H. Lee, Bahar Artım-Esen, Anisur Rahman, Paul Michael Maciocia, Carola G. Vinuesa
The paper shows that autoantibody production in lupus is sustained by continuous B cell differentiation, not long-lived plasma cells, and relapse after CAR-T therapy occurs via new B cells.
bioRxiv · Oct 20, 2025 · PreprintImmunology