Author

Linbu Liao

University of CopenhagenORCID 0000-0002-6103-0700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

António M. PalmaiD· 2 shared Esha MadaniD· 2 shared Jose TrevinoiD· 2 shared Junil KimiD· 2 shared Kyoung‐Jae WoniD· 2 shared Paul B. FisheriD· 2 shared Rajan GognaiD· 2 shared Robert A. WinniD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersBioinformatics

António M. PalmaORCID

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2 papers

Recent·Most cited

SC2Spa: a deep learning based approach to map transcriptome to spatial origins at cellular resolution

Linbu Liao, Esha Madan, António M. Palma, Hyobin Kim, Amit Kumar, Praveen Bhoopathi, Robert A. Winn, Jose Trevino, Paul B. Fisher, Cord Brakebusch, Gahyun Kim, Junil Kim, Rajan Gogna, Kyoung‐Jae Won

SC2Spa maps single-cell RNA-seq data to spatial coordinates using deep learning, improving resolution for low-resolution spatial transcriptomics data and identifying spatially variable genes.

BMC Bioinformatics · Jun 2, 2025Peer-reviewedBioinformatics

Neighbor-specific gene expression revealed from physically interacting cells during mouse embryonic development

Junil Kim, Michaela Rothová, Esha Madan, Siyeon Rhee, Guangzheng Weng, António M. Palma, Linbu Liao, Eyal David, Ido Amit, Morteza Chalabi Hajkarim, Vignesh Vudatha, Andrés Gutiérrez-García, Eduardo Moreno, Robert A. Winn, Jose Trevino, , Kyoung‐Jae Won

The paper introduces PIC-seq to study cell-cell contact-specific gene expression during mouse embryonic development and identifies novel gene expression signatures dependent on neighboring cell types.

Proceedings of the National Academy of Sciences · Jan 3, 2023Peer-reviewedDevelopmental Biology