Eyal David

Single-cell eQTL mapping in 5.4 million PBMCs from 1,925 individuals with matched WGS finds common-variant eQTLs for 83% and rare-variant signals for 47% of 21,404 genes.

This study develops PD-1-targeted CAR-T cells that specifically eliminate synovium-associated T cells and reduce arthritis in experimental models.

This study engineers CAR T cells to promote tissue repair in CNS injury by modulating immune responses and reducing inflammation.

The paper shows that T cell-derived IFN-γ suppresses TFH differentiation and antibody responses by acting through dendritic cells, not directly on CD4+ T cells.

This study shows that TMPRSS2-ERG fusion promotes resistance to antiandrogens by interacting with GR, suggesting combined GR and AR inhibition could benefit tERG-positive prostate cancer patients.

The paper identifies TGF-β signaling as a regulator of natural killer cell function in both pregnancy and tumor progression by analyzing immune compartment dynamics in human and mouse models.

The paper examines circadian gene expression in microglia across health and Huntington's disease, finding disrupted rhythms in symptomatic mice.

The paper introduces PIC-seq to study cell-cell contact-specific gene expression during mouse embryonic development and identifies novel gene expression signatures dependent on neighboring cell types.

The paper uses single-cell RNA sequencing to study mouse limb development, identifying progenitor states and their differentiation into skeletal elements in a spatiotemporal pattern.

The paper introduces DestVI, a method for multi-resolution spatial transcriptomics analysis that captures continuous cell state variation, and applies it to study inflammation in lymph nodes and tumors.