Author

Allison Knupp

University of WashingtonORCID 0000-0003-3645-9692Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jessica E. YoungiD· 2 shared Aimee J. AylwardiD· 1 shared C. Andrew Williams· 1 shared Cheryl PaniD· 1 shared Chizuru Kinoshita· 1 shared Courtney R. BenoitiD· 1 shared David Alan BennettiD· 1 shared Duc Minh DuongiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Jessica E. YoungORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintFeb 25, 2023

Cell-type-specific regulation of APOE levels in human neurons by the Alzheimer's disease risk gene SORL1

Hyo Lee, Aimee J. Aylward, Richard V. Pearse…·Tracy L. Young‐Pearse

This study shows that SORL1 loss reduces APOE levels specifically in neurons and astrocytes, linking SORL1 and APOE to Alzheimer's disease risk through distinct pathways.

4 citations

humanbulk RNA-seq

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NeurosciencebioRxivPreprintJul 31, 2022

Pharmacologic Stabilization of Retromer Rescues Endosomal Pathology Induced by Defects in the Alzheimer's gene SORL1

Swati Mishra, Allison Knupp, Chizuru Kinoshita…·Jessica E. Young

The paper tests if a retromer stabilizing drug, TPT-260, can correct endosomal and Alzheimer's-related pathologies in neurons with SORL1 variants.

9 citations

humanexperimental assay

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