Eric Largy

The paper integrates ion mobility spectrometry with HDX/MS to better resolve conformational ensembles in DNA oligonucleotides, showing improved kinetic analysis and distinction of non-specific cation binding.

This study determines the structure of a dopamine-binding DNA aptamer using NMR, revealing an unconventional DNA fold distinct from typical DNA structures and providing insights into its specificity and potential applications in biosensor design.

Structure providers for 18 CASP16 nucleic acid targets find blind predictions capture secondary structure but miss non-canonical interactions, backbone kinks, ligand sites, and intermolecular interfaces.

This study identifies helical foldamers with quinoline and pyridine units as selective G-quadruplex ligands, showing preference for parallel structures and sequence variants.