Bradon R. McDonald

Analysis of plasma DNA fragmentation patterns from dried blood spots

This study shows that plasma DNA fragmentation analysis from dried blood spots can detect cancer with machine learning, offering a cost-effective method for early cancer detection in resource-limited settings.

Analysis of fragment ends in plasma DNA from patients with cancer

Analyzing the positioning and nucleotide sequence at fragment ends in plasma DNA may enable cancer diagnostics.

Sub-nucleosomal organization in urine cell-free DNA

This study characterizes urine cfDNA fragmentation patterns and shows they reflect sub-nucleosomal organization, with potential for cancer diagnostics.

Feasibility and promise of circulating tumor DNA analysis in dogs with naturally-occurring sarcoma.

This study demonstrates the feasibility of ctDNA analysis in dogs with hemangiosarcoma using shallow whole genome sequencing, showing higher ctDNA fractions in malignant tumors compared to benign ones.

Detection of residual disease after neoadjuvant therapy in breast cancer using personalized circulating tumor DNA analysis

A personalized ctDNA test achieves high accuracy for residual disease detection after neoadjuvant therapy in breast cancer.