Elizabeth D. Hutchins

The paper identifies extracellular vesicles (sEVs) from EBV-transformed B-cells as a vehicle for exporting host DNA and EBV EBER1 RNA, linking peripheral EBV infection to distal tissue signaling in MS.

This study provides a multiomics resource of cancer extracellular vesicles, showing correlations between LO proteins and prostate cancer progression, and demonstrating the feasibility of single-cell RNA-Seq on EVs.

The paper identifies decreased SNCA expression in Parkinson's Disease blood samples after correcting for immune cell effects, suggesting it as a potential transcriptomic biomarker.

This study identifies 1,111 PD-associated RNAs in blood and develops a multi-omics model with AUC 0.89 for PD diagnosis, offering insights into pathobiology and potential clinical applications.

The paper presents a multi-layered molecular dataset from iPSC-derived dopaminergic neurons to model Parkinson's disease genetic risk and provides a data browser for accessing these resources.

The paper compares transcriptomic responses in skeletal muscle and extracellular vesicles after traditional and high-intensity exercise in young adults, finding more consistent gene responses to traditional exercise and unique microRNA responses to high-intensity training.

This paper develops an automated ML model to predict Parkinson's Disease using multi-modal data, achieving high AUC scores and constructing gene networks relevant to PD.

The paper analyzes sncRNA-seq data from the PPMI cohort to identify miRNAs associated with Parkinson's disease progression and systemic inflammation.

This study characterizes urine cfDNA fragmentation patterns and shows they reflect sub-nucleosomal organization, with potential for cancer diagnostics.

The paper quantifies technical variability in whole blood transcriptome data from the PPMI study using pooled reference samples and describes the dataset's availability.

This study examines C9orf72 ALS/FTD patient-derived iPSC-microglia mono-cultures, finding they form RNA foci, have reduced C9orf72 protein, and show endosomal-lysosomal dysfunction, but no significant microglial-enriched gene expression differences.