Evon Poon

Exploiting the polypharmacology of alectinib for synergistic RNA splicing disruption with RBM39 degraders

This paper combines RBM39 degradation and SRPK1 inhibition to disrupt RNA splicing in neuroblastoma, showing synergistic anti-cancer effects in cell lines and a mouse model.

OXPHOS TARGETING OF MYCN-AMPLIFIED NEUROBLASTOMA

This study identifies a synergistic combination of DPI and MitoQ that targets mitochondrial metabolism in MYCN-amplified neuroblastoma cells, enhancing chemotherapeutic efficacy.

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

Glutamine addiction is targetable via altering splicing of nutrient sensors and epitranscriptome regulators

This study shows PRMT5 inhibition targets MNA neuroblastoma by altering splicing of nutrient sensors and epitranscriptome regulators, leading to growth inhibition and apoptosis.

GSK3 Controls Migration of the Neural Crest Lineage

This study identifies GSK3's role in regulating neural crest migration and shows its relevance in neuroblastoma cell migration.