Walter Mancia

Fate plasticity of interneuron specification

This study shows that the identity of MGE-derived cortical interneurons can be dynamically influenced by their environment, with human 3D models promoting Pvalb expression over Sst.

Neural Stem Cell Relay from B1 to B2 cells in the adult mouse Ventricular-Subventricular Zone

This study identifies B2 cells as the primary neural stem cells in the adult mouse V-SVZ, replacing B1 cells postnatally to sustain neurogenesis.

The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex.

The paper shows that deletion of the Pcdhγc4 isoform increases cortical interneuron cell death, while viral expression rescues it, highlighting its critical role in regulating survival during programmed cell death.

Developmental origin and local signals cooperate to determine septal astrocyte identity

The paper shows that intrinsic developmental origins and local signals shape septal astrocyte identity through distinct molecular and morphological features in medial and lateral septal nuclei.

Molecular diversity and lineage commitment of human interneuron progenitors

The paper identifies molecular subtypes of human interneuron progenitors and immature interneurons using single-cell RNA sequencing and compares them to mouse data, revealing species-specific gene programs.

An Xist-dependent protein assembly mediates Xist localization and gene silencing

The paper shows that Xist RNA forms a protein condensate with binding proteins to establish the Xi-compartment and maintain gene silencing.

Clustered γ-Protocadherins Regulate Cortical Interneuron Programmed Cell Death.

This study identifies Pcdh-γ cluster genes as critical regulators of programmed cell death in cortical interneurons through cell-autonomous and non-cell autonomous mechanisms.