Agustin Almoril-Porras

Long-term editing of brain circuits in mice using an engineered electrical synapse

The paper engineers an electrical synapse in mice using fish connexins to modulate neural circuits and behavior.

Specific configurations of electrical synapses filter sensory information to drive choices in behavior

The paper shows that electrical synapses in C. elegans filter sensory information to guide context-specific behavioral choices by modulating neuronal excitability and integration of temperature stimuli.

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9

This study identifies ATG-9 trafficking as a mechanism linking presynaptic autophagy to the synaptic vesicle cycle in C. elegans.

Long-term precision editing of neural circuits in mammals using engineered gap junction hemichannels

The paper develops engineered gap junction hemichannels to enable precise, long-term neural circuit editing in mammals by enabling communication between distinct cell types.

Integration of plasticity mechanisms within a single sensory neuron of C. elegans actuates a memory

The paper shows how two plasticity mechanisms in a single C. elegans neuron encode thermosensory information and actuate a temperature-preference memory.