George B. Butler

This study shows cancer cells survive genotoxic chemotherapy by entering a drug-tolerant persister state involving mitotic bypass and endocycling, which can be targeted by inhibiting WEE1 or Myt1.

This study identifies genes linked to cancer risk variation across species, showing indirect effects on body size dominate cancer suppression, while direct effects increase tumour prevalence.

The Vertebrate Genomes Project Phase I provides high-quality reference genomes for 816 species, enabling evolutionary and conservation insights across vertebrates.

The paper shows that metastatic tumors exhibit more punctuational molecular evolution compared to primary tumors, indicating different evolutionary modes in cancer progression.