Bradley W. Wright

This paper develops a system to produce high-purity circular RNAs by minimizing linear RNA byproducts through optimized circularization and transcript termination strategies.

This study shows that removing gene overlaps in a bacteriophage genome reduces viral replication efficiency, highlighting the importance of gene overlap for viral function.

The paper measures the orthogonality of an engineered amber initiator tRNA in a genomically recoded E. coli strain and finds it increases reporter expression without off-target translation.