Rina Fujiwara

This paper develops a system to produce high-purity circular RNAs by minimizing linear RNA byproducts through optimized circularization and transcript termination strategies.

The paper shows that IntS6 recruits PP2A to regulate transcription termination efficiency at specific genes, highlighting the phosphatase module's selective role in Integrator complex function.

The paper shows that Integrator complex depletion disrupts histone gene expression timing by dispersing transcription machinery clusters.

The paper investigates whether circular or linear RNA topology affects Target RNA-Directed MicroRNA Degradation (TDMD), finding that circular RNAs can inhibit while linear forms can drive TDMD.