Author

Joshua M. Spurrier

Yale UniversityORCID 0000-0002-6267-7231Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:snRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Stephen M. StrittmatteriD· 2 shared Amy Yu· 1 shared Angela KimiD· 1 shared Anthony G. BoghdadiiD· 1 shared Austin J. StoneriD· 1 shared Benjamin CaoiD· 1 shared Chao ZhengiD· 1 shared Charles BrenneriD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Stephen M. StrittmatterORCID

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3 papers

Recent·Most cited

Cancer BiologyMolecular Cancer TherapeuticsPeer-reviewedApr 22, 2026

NAPRT expression and epigenetic regulation in pediatric rhabdomyosarcoma as a potential biomarker for NAMPT inhibition

Angela Kim, Prateek Bhardwaj, Collin D. Heer…·Juan C. Vasquez

This study evaluates NAPRT expression and epigenetic regulation in pediatric rhabdomyosarcoma as a potential biomarker for NAMPT inhibitor therapy.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintFeb 15, 2023

Neuronal Transcriptome Disruption, Tau Accumulation and Synapse Loss in Alzheimer's Knock-in Mice Require Cellular Prion Protein

Austin J. Stoner, Li Fu, LaShae Nicholson…·Stephen M. Strittmatter

This study shows that PrPC is necessary for synapse loss, phospho-tau accumulation, and neuronal gene expression changes in Alzheimer's knock-in mice, suggesting targeting the Aβo-PrPC interaction could prevent these pathologies.

1 citation

𝕏 PostBluesky

NeurosciencebioRxivPreprintMay 8, 2020

Primate-specific response of astrocytes to stroke limits peripheral macrophage infiltration

Anthony G. Boghdadi, Joshua M. Spurrier, Leon Teo…·James A. Bourne

The paper identifies primate-specific astrocyte responses to stroke, showing NogoA limits macrophage infiltration and suggests therapeutic targeting.

6 citations

non-human primatesnRNA-seq

𝕏 PostBluesky