Li Fu

The paper identifies a decline in phosphatidylcholine synthesis as a driver of mitochondrial aging that can be reversed by dietary interventions in both worms and human cells.

This study identifies a paracrine-to-autocrine GREM1 signaling shunt in colorectal cancer that promotes metastasis via ACVR1C, highlighting a mechanism of signaling autonomy in advanced stages.

This study shows UVB exposure mimics dietary restriction by altering mitochondrial bioenergetics in C. elegans and human cells, triggering metabolic re-wiring and requiring mitochondrial fusion for recovery.

This study shows that PrPC is necessary for synapse loss, phospho-tau accumulation, and neuronal gene expression changes in Alzheimer's knock-in mice, suggesting targeting the Aβo-PrPC interaction could prevent these pathologies.