Neuronal Transcriptome Disruption, Tau Accumulation and Synapse Loss in Alzheimer's Knock-in Mice Require Cellular Prion Protein
Austin J. Stoner, Li Fu, LaShae Nicholson, Chao Zheng, Takuya Toyonaga, Joshua M. Spurrier, Will Laird, Zhengxin Cai, Stephen M. Strittmatter
This study shows that PrPC is necessary for synapse loss, phospho-tau accumulation, and neuronal gene expression changes in Alzheimer's knock-in mice, suggesting targeting the Aβo-PrPC interaction could prevent these pathologies.
bioRxiv · Feb 15, 2023 · PreprintNeuroscience