Author

Tian‐Min Fu

Boston Children's HospitalORCID 0000-0002-6281-1752Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Zhangfei SheniD· 2 shared Akiko IwasakiiD· 1 shared Anthony D. RishiD· 1 shared Chen WangiD· 1 shared Elizabeth FosuahiD· 1 shared Hao WuiD· 1 shared Ila A. MaratheiD· 1 shared Judy LiebermaniD· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

Zhangfei ShenORCID

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3 papers

Recent·Most cited

Topological rearrangements activate the HerA-DUF anti-phage defense system

Anthony D. Rish, Elizabeth Fosuah, Zhangfei Shen, Ila A. Marathe, Vicki Hopper Wysocki, Tian‐Min Fu

The paper identifies topological rearrangements in the HerA-DUF complex that activate the anti-phage defense system, challenging the idea that oligomerization alone is sufficient for immune signaling.

Molecular Cell · Oct 24, 2024Peer-reviewedBiochemistry

DdmDE eliminates plasmid invasion by DNA-guided DNA targeting

Xiaoyuan Yang, Zhangfei Shen, Chen Wang, Kotaro Nakanishi, Tian‐Min Fu

This study elucidates the mechanism of the DdmDE system in eliminating plasmids through DNA-guided targeting and cleavage.

Cell · Aug 22, 2024Peer-reviewedBiophysics

Targeting Stem-loop 1 of the SARS-CoV-2 5'UTR to suppress viral translation and Nsp1 evasion

Setu M. Vora, Pietro Fontana, Tianyang Mao, Valerie Leger, Ying Zhang, Tian‐Min Fu, Judy Lieberman, Lee Gehrke, Ming Shi, Longfei Wang, Akiko Iwasaki, Hao Wu

SARS-CoV-2 5' UTR stem-loop 1 (SL1) lets reporters escape Nsp1 translational shutdown. LNA antisense oligos against SL1 restore Nsp1 suppression and reduce infected Vero E6 cells.

Proceedings of the National Academy of Sciences · Feb 11, 2022Peer-reviewedMolecular Biology✦ In-depth digest