Jing Chen

Distinct Programs Drive Organ Development and Regeneration

The paper identifies Pou2f3 as a master regulator of a novel intermediate cell state critical for regeneration but not organ physiology in mammary glands, challenging the idea that regeneration recapitulates development.

Biomaterial Scaffold Stiffness Influences the Foreign Body Reaction, Tissue Stiffness, Angiogenesis and Neuroregeneration in Spinal Cord Injury

Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations

This study characterizes hearing loss in mice with human MIR96 mutations and identifies a therapeutic candidate that delays hearing loss progression in heterozygous mice.

Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice.

This study shows that Caprin1 deletion in mice causes progressive hearing loss and impairs recovery from noise-induced hearing loss.

The coupling of global brain activity and cerebrospinal fluid inflow is correlated with Alzheimer's disease related pathology

The paper shows that coupling between global brain activity and CSF inflow correlates with Alzheimer's disease pathology using ADNI data.