Anwen Bullen

Estrogen-related receptor gamma is required for normal auditory innervation and is essential for hearing.

This study identifies ESRRG as essential for normal auditory innervation and hearing by showing that its loss causes early-onset hearing loss and synaptic defects in mice.

KLHDC7B, a novel gene associated with age-related hearing loss in humans, is required for the maintenance of hearing in mice.

This paper identifies KLHDC7B as a gene associated with age-related hearing loss in humans and validates its role in hearing maintenance using two mouse models.

Mitochondrial dynamics regulate cell size in the developing cochlea

The paper shows mitochondrial dynamics regulate cell size in developing cochlear hair cells, with fusion affecting proximal and distal HC morphology along the tonotopic axis.

Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice.

This study shows that Caprin1 deletion in mice causes progressive hearing loss and impairs recovery from noise-induced hearing loss.

ERBB2 is a Key Mediator in Hearing Restoration in Noise-Deafened Young Adult Mice

This study shows that activating ERBB2 signaling in cochlear supporting cells can partially reverse noise-induced hearing loss in mice.