Gareth Haydn Williams

This study investigates the role of DAGLα/β and 2-AG in Parkinson's disease, finding potential links between DAGL dysfunction and non-motor symptoms like depression.

The paper identifies cardiotonic steroids as potential repurposing candidates for lithium treatment of severe depression based on transcriptional and epidemiological analyses.

The paper shows that synaptotoxic forms of amyloid-beta and alpha-synuclein act through the same Wnt/PCP pathway to cause dendritic spine loss in neurodegenerative diseases.

The paper develops a predictive model for compound-protein interactions using concatenated vectorization of compound and protein features, achieving results comparable to more complex methods.

This study characterizes hearing loss in mice with human MIR96 mutations and identifies a therapeutic candidate that delays hearing loss progression in heterozygous mice.

This study shows fasudil reverses gene expression patterns associated with neurodegenerative disease in Alzheimer's model mice.

The paper identifies small molecules that differentially modulate oligodendrocyte generation and myelination, with LY294002 showing bipartite effects at varying concentrations.

The paper identifies cardiovascular and infectious disease mechanisms linked to atypical antipsychotic side-effects using transcriptome analysis and bioinformatics.

The paper identifies 19 compounds from the CMAP library that show significant inverse correlation with Alzheimer's disease transcriptome signatures and pass in vitro screening assays.