Critical role for the TGF-β1/mTORC1 signalling axis in defining the transcriptional identity of CTHRC1+ pathologic fibroblasts
Jo-Anne A M Wilson, Rachel Walters, Greg Contento, Madeleine Rossanese, Delphine Guillotin, Alexander I. Ward, Robert E. Hynds, Mariam Jamal‐Hanjani, Naftali Kaminski, Silvia Parolo, Manuela Platé, Rachel Clare Chambers
This study shows that the TGF-β1/mTORC1 signalling axis regulates the transcriptional identity of CTHRC1+ fibroblasts in IPF, supporting mTORC1 as a therapeutic target.
Science Advances · Sep 2, 2026Peer-reviewedCell Biology