Antonio Marino

This study shows oxidative stress reduces DUB activity in aging brains, which can be reversed with antioxidants, suggesting a reversible cause of proteostasis decline.

This study identifies lonafarnib as a potential therapy for progeria-related cardiac senescence by activating autophagy and reducing progerin expression in human and mouse models.

This study identifies age-related changes in ubiquitylation, acetylation, and phosphorylation sites in mouse brains and finds conserved effects in killifish, linking proteasome inhibition to aging ubiquitylome remodeling.

The paper shows that aging in killifish brains reduces basic amino acid-rich proteins through translation pausing, not transcription or proteasome issues, revealing a vulnerability in nucleic-acid protein biogenesis.