Shifting Redox Reaction Equilibria on Demand Using an Orthogonal Redox Cofactor
Derek Aspacio, Yulai Zhang, Youtian Cui, Emma Luu, Edward J. King, William B. Black, Sean Perea, Qiang Zhu, Yongxian Wu, Ray Luo, Justin B. Siegel, Han Li
This paper introduces Nox Ortho, an enzyme that enables precise control of redox reactions using NMN+ as a cofactor, achieving high specificity and enabling chiral-pure product synthesis.
Nature Chemical Biology · Aug 13, 2024Peer-reviewedSynthetic Biology