Author

Derek Aspacio

University of California, IrvineORCID 0000-0002-8210-1811Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1

Frequent Co-Authors

Edward J. King· 2 shared Han LiiD· 2 shared William B. BlackiD· 2 shared Danielle Bever· 1 shared Emma LuuiD· 1 shared Justin B. SiegeliD· 1 shared Linyue Zhang· 1 shared Qiang ZhuiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

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10 top collaborators · 35 mutual co-author links

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2 shared papersSynthetic Biology

Edward J. King

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2 papers

Recent·Most cited

Synthetic BiologyNature Chemical BiologyPeer-reviewedAug 13, 2024

Shifting Redox Reaction Equilibria on Demand Using an Orthogonal Redox Cofactor

Derek Aspacio, Yulai Zhang, Youtian Cui…·Han Li

This paper introduces Nox Ortho, an enzyme that enables precise control of redox reactions using NMN+ as a cofactor, achieving high specificity and enabling chiral-pure product synthesis.

44 citationstop 2%

E. coliexperimental assay

𝕏 PostBluesky

Synthetic BiologyMicrobial Cell FactoriesPeer-reviewedJul 27, 2020

Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor

William B. Black, Derek Aspacio, Danielle Bever…·Han Li

This paper engineers Escherichia coli to biosynthesize nicotinamide mononucleotide (NMN+) for use in cell-free biosynthesis, achieving a 130-fold increase in intracellular NMN+ levels.

67 citations

E. coliexperimental assay

𝕏 PostBluesky