Author

Yulai Zhang

University of California, IrvineORCID 0000-0003-3257-1433Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein design· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Edward J. King· 2 shared Emma LuuiD· 2 shared Han LiiD· 2 shared Justin B. SiegeliD· 2 shared Sean PereaiD· 2 shared William B. BlackiD· 2 shared Youtian CuiiD· 2 shared Derek AspacioiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersMolecular Biology

Edward J. King

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2 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedSep 12, 2026

Reprogramming the Rossmann Fold Signature Motif Creates Orthogonal Redox Biocatalysts

Yu Ping, Jin Young Kim, Minh-Anh L. Dinh…·Han Li

The paper reprograms the Rossmann fold motif to create NMN+-specific enzymes that avoid NAD(P)/H interactions, achieving high specificity and productivity in biotransformation.

DOI 10.1038/s41467-026-77633-7

proteomicsstatistical model

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Synthetic BiologyNature Chemical BiologyPeer-reviewedAug 13, 2024

Shifting Redox Reaction Equilibria on Demand Using an Orthogonal Redox Cofactor

Derek Aspacio, Yulai Zhang, Youtian Cui…·Han Li

This paper introduces Nox Ortho, an enzyme that enables precise control of redox reactions using NMN+ as a cofactor, achieving high specificity and enabling chiral-pure product synthesis.

44 citationstop 2%

E. coliexperimental assay

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