Inês Caldeira Brás

This study identifies proteomic signatures in CSF and serum from HDClarity that can stage and stratify Huntington disease across clinical stages with high accuracy.

The paper shows that loss of interruption in HTT CAG repeats increases somatic expansion and MSN loss in HD, with greater effects in patients with CAG-CCG LOI.

This study investigates neuron-derived extracellular vesicles as non-invasive biomarkers for HTT protein and RNA in Huntington disease, showing subtype-specific differences in HTT levels.

This study compares the release and effects of alpha-synuclein, Tau, and huntingtin in neuronal cells, showing similar release pathways and impacts on neuronal activity and inflammation.

The paper characterizes ectosomes and exosomes proteomes and shows they modulate neuronal activity differently.