Livio Trusolino

This study identifies Pdk1-high metabolic cancer cells in colorectal tumors that drive aggressive behavior through interferon signaling.

This study shows that TGF-β1-induced differentiation in colorectal cancer organoids enhances chemotherapy response by reducing clonogenic capacity and increasing oxaliplatin cytotoxicity.

This study identifies on-target WRN mutations as resistance mechanisms in MSI cancer cells to WRN helicase inhibitors and suggests combination therapies to prevent resistance.

The paper measures mutation rates in microsatellite stable colorectal cancers and finds they vary between tumors and increase during metastasis.

The paper trains an ensemble classifier to predict cetuximab sensitivity in colorectal cancer PDXs using multi-omic data, achieving high accuracy and demonstrating its utility for therapeutic biomarker development.

CONNECTOR analyzes longitudinal tumor growth data to identify clusters and reveal new molecular associations with therapy response.

INKA identifies active phosphokinases in cancer by integrating kinase and substrate phosphorylation data from phosphoproteomics.