Author

Francesco Paolo Sassi

Candiolo Cancer InstituteORCID 0000-0002-4741-0408Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Andrea BertottiiD· 3 shared Livio TrusolinoiD· 3 shared Elena GrassiiD· 2 shared Marco VivianiiD· 2 shared Martina FerriiD· 2 shared Alberto BardelliiD· 1 shared Anastasia Kavasakali· 1 shared Andrea SottorivaiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

Andrea BertottiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

On-target mutations confer resistance to WRN helicase inhibitors in Microsatellite Unstable Cancer Cells.

Gabriele Picco, Yanhua Rao, Angham Al Saedi, Samantha J. Walker, Shriram G. Bhosle, Yang Lee, Sara F. Vieira, María Ana García-Casado, Gilberto Valdes Garcia, Kieron May, Francesco Paolo Sassi, Inigo Barrio Hernandez, Mamta Sharma, Cansu Dinçer, Theo Bell, , Mathew J. Garnett

This study identifies on-target WRN mutations as resistance mechanisms in MSI cancer cells to WRN helicase inhibitors and suggests combination therapies to prevent resistance.

bioRxiv · Dec 27, 2025 · PreprintCancer Biology

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer

Elena Grassi, Valentina Vurchio, George D. Cresswell, Irene Catalano, Barbara Lupo, Francesco Paolo Sassi, Francesco Galimi, Sofia Borgato, Martina Ferri, Marco Viviani, Simone Pompei, Gianvito Urgese, Bingjie Chen, Eugenia Rosalinda Zanella, Francesca Cottino, , Andrea Bertotti

The paper measures mutation rates in microsatellite stable colorectal cancers and finds they vary between tumors and increase during metastasis.

Science Translational Medicine · May 21, 2025Peer-reviewedCancer Biology

CONNECTOR, fitting and clustering of longitudinal data to reveal a new risk stratification system.

Simone Pernice, Roberta Sirovich, Elena Grassi, Marco Viviani, Martina Ferri, Francesco Paolo Sassi, Luca Alessandrì, Dora Tortarolo, Raffaele Calogero, Livio Trusolino, Andrea Bertotti, Marco Beccuti, Martina Olivero, Francesca Cordero

CONNECTOR analyzes longitudinal tumor growth data to identify clusters and reveal new molecular associations with therapy response.

Bioinformatics · Apr 20, 2023Peer-reviewedBioinformatics