Sage E Nelson

The paper introduces HARP, a yeast-based platform for discovering protease inhibitors, and demonstrates its ability to isolate low-nanomolar-range nanobodies against specific proteases.

The paper introduces PERRC, a platform for engineering protease specificity by controlling reactant residence time, resulting in a protease variant with high selectivity for a closely related substrate.

This paper expands the YESS system by creating integrative plasmids for modular and uniform activity reporting of PTM-enzymes in yeast.