Author

Seyednima Ajayebi

University of Florida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Organism:yeast· 1

Frequent Co-Authors

Carl A. DenardiD· 2 shared Sage E NelsoniD· 2 shared Samantha G. MartinuseniD· 2 shared Alberto Perez· 1 shared Amit Kumar DuttaiD· 1 shared Amor A. MenezesiD· 1 shared Cassidy F Simas· 1 shared Cianna Scutero· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSynthetic Biology

Carl A. DenardORCID

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2 papers

Recent·Most cited

High-throughput Activity Reprogramming of Proteases (HARP)

Samantha G. Martinusen, Ethan W Slaton, Seyednima Ajayebi, Marian A Pulgar, Cassidy F Simas, Sage E Nelson, Amit Kumar Dutta, Julia T Besu, Steven D. Bruner, Carl A. Denard

The paper introduces HARP, a yeast-based platform for discovering protease inhibitors, and demonstrates its ability to isolate low-nanomolar-range nanobodies against specific proteases.

ACS Chemical Biology · Sep 23, 2025Peer-reviewedSynthetic Biology

PERRC: Protease Engineering with Reactant Residence Time Control

Sage E Nelson, Jokent T. Gaza, Seyednima Ajayebi, Ron Masse, Raymond Pho, Cianna Scutero, Samantha G. Martinusen, Lawton F. Long, Amor A. Menezes, Alberto Perez, Carl A. Denard

The paper introduces PERRC, a platform for engineering protease specificity by controlling reactant residence time, resulting in a protease variant with high selectivity for a closely related substrate.

ACS Synthetic Biology · May 19, 2025Peer-reviewedSynthetic Biology