Carl A. Denard

Photothermal Recycling Biosensing for Continuous, Sensitive Molecular Quantification

This paper introduces a photothermal recycling biosensing method for continuous, sensitive molecular quantification in complex biological fluids.

High-throughput Activity Reprogramming of Proteases (HARP)

The paper introduces HARP, a yeast-based platform for discovering protease inhibitors, and demonstrates its ability to isolate low-nanomolar-range nanobodies against specific proteases.

Rational Development of Recombinant ELP Bolaamphiphiles for the Controlled Construction of Multifunctionalized Globular Protein Vesicles

This paper develops ELP bolaamphiphiles for constructing multifunctional globular protein vesicles, showing their structural and mechanical properties.

PERRC: Protease Engineering with Reactant Residence Time Control

The paper introduces PERRC, a platform for engineering protease specificity by controlling reactant residence time, resulting in a protease variant with high selectivity for a closely related substrate.

A scalable genetic tool for the functional analysis of the signal recognition particle.

This paper develops a yeast haploid model to study SRP54 mutations and their functional consequences, revealing dominant-negative phenotypes and growth defects associated with specific mutations.

Modular and integrative activity reporters enhance biochemical studies in the yeast ER.

This paper expands the YESS system by creating integrative plasmids for modular and uniform activity reporting of PTM-enzymes in yeast.

A comprehensive survey of coronaviral main protease active site diversity in 3D: Identifying and analyzing drug discovery targets in search of broad specificity inhibitors for the next coronavirus pandemic

The paper analyzes the diversity of coronaviral main protease active sites to identify potential broad-spectrum inhibitors for future pandemics.