Ruolin Fan

This study shows that reducing Letm1 increases mitochondrial Ca2+ retention, overactivates metabolism, and enhances long-term memory in flies and mice.

The paper shows that synaptic plasticity drives localized mitochondrial ATP synthesis in dendritic spines, independent of CaMKII and ER, and that this process is essential for maintaining synaptic function.

This paper introduces new organellar Ca2+ sensors with tunable colors and improved brightness and photostability for multiplexed measurements in different organelles.

The paper identifies periodic ER-PM junctions in dendrites that enable long-range Ca2+ signal integration through local spine activation and ryanodine receptor-dependent Ca2+ release.

The paper identifies VAP as a protein that stabilizes mitochondria near synapses to support synaptic plasticity and determines the spatial extent of dendritic segments involved.