Eric R. Schreiter

vFLIM: Machine Learning-enabled Light Sheet Fluorescence Lifetime Imaging

The paper introduces a machine learning-enabled pipeline for volumetric FLIM imaging in living systems, enabling long-term and high-speed data acquisition and analysis.

WHaloForce enables chemigenetic imaging of molecular tension in living cells and animals

WHaloForce is a chemigenetic tension sensor that enables quantitative imaging of molecular forces in living cells and animals, revealing distinct force patterns in different tissues.

Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species

This study shows that reducing Letm1 increases mitochondrial Ca2+ retention, overactivates metabolism, and enhances long-term memory in flies and mice.

Synchronous Ensembles of Hippocampal CA1 Pyramidal Neurons During Novel Exploration

The paper investigates synchronous neuronal ensembles in hippocampal CA1 pyramidal neurons during novel exploration and finds they are phase-locked to theta waves and correlate with place cell activity.

In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors

The paper introduces a far-red dopamine sensor, HaloDA1.0, enabling multiplex imaging of neurochemical networks in vivo with high sensitivity and versatility.

Far-red fluorescent genetically encoded calcium ion indicators

This paper introduces two new far-red fluorescent GECIs, FR-GECO1a and FR-GECO1c, characterized for their Ca2+ sensitivity and performance in neuronal imaging.

An expanded palette of bright and photostable organellar Ca2+ sensors

This paper introduces new organellar Ca2+ sensors with tunable colors and improved brightness and photostability for multiplexed measurements in different organelles.

A novel rhodopsin-based voltage indicator for simultaneous two-photon optical recording with GCaMP in vivo

The paper introduces a novel rhodopsin-based voltage indicator, 2Photron, enabling simultaneous two-photon recording of spiking and subthreshold voltage with GCaMP in awake mice.

All-optical reporting of inhibitory receptor driving force in the nervous system.

This paper introduces ORCHID, an all-optical method to measure inhibitory receptor driving forces, demonstrating its accuracy and application in neurons and astrocytes.

Epigenetic repression of cFos supports sequential formation of distinct spatial memories

The paper investigates how {Delta}FosB inhibition affects cFos expression and memory formation, finding that epigenetic repression of cFos supports sequential spatial memory formation.

A modular chemigenetic calcium indicator enables in vivo functional imaging with near-infrared light

The paper introduces WHaloCaMP, a near-infrared calcium indicator, and demonstrates its use in imaging calcium responses in various organisms.

Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission

This paper develops improved glutamate indicators with faster activation kinetics and better synaptic localization for imaging synaptic transmission in neurons.

Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator

The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.

Fast and sensitive GCaMP calcium indicators for imaging neural populations

The paper develops fast and sensitive GCaMP indicators for neural activity imaging, achieving ultra-fast kinetics and high sensitivity.

A general approach to engineer positive-going eFRET voltage indicators

The paper describes engineering eFRET voltage indicators with positive-going fluorescence responses by modifying microbial rhodopsins.

jYCaMP: An optimized calcium indicator for two-photon imaging at fiber laser wavelengths

The paper introduces jYCaMP1, a calcium indicator optimized for two-photon imaging at wavelengths above 1000 nm, showing improved performance in mice and flies.

Freeze-frame imaging of synaptic activity using SynTagMA

The paper introduces SynTagMA, a tool to mark active synapses in a 2-second window, and provides software for analyzing large datasets of synaptic activity.

Bright and tunable far-red chemigenetic indicators

The paper introduces a new platform for chemigenetic fluorescent indicators with bright, far-red emission and tunable properties for detecting single action potentials in neurons.

rsCaMPARI: an erasable marker of neuronal activity

The paper introduces rsCaMPARI, an erasable neuronal activity marker that allows for marking, erasing, and remarking of active neuron populations in zebrafish.

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging

The paper introduces a new genetically encoded voltage indicator, Voltron, which improves brightness and photostability for extended in vivo voltage imaging in mice, zebrafish, and fruit flies.

Kilohertz frame-rate two-photon tomography

This paper introduces a two-photon imaging technique that achieves high-speed, high-resolution imaging of neural activity in mice at over 1 kHz frame rates.

High-performance GFP-based calcium indicators for imaging activity in neuronal populations and microcompartments

Structure-guided mutagenesis of GCaMP6 plus neuron-based screening yields a jGCaMP7 family, each variant tuned to a different regime: single spikes, neurites and neuropil, or population imaging.